SMARCA4 and acute liver failure: Recently, we have made several discoveries that portray BRG1 as a critical modulator of liver pathologies: mice with a selective deficiency of BRG1 in hepatocytes are protected from acetaminophen-induced acute liver failure and diet induced steatosis (Kong et al., 2018; Li et al., 2018a, b, 2019b, c; Fan et al., 2019, 2020; Liu et al., 2019a).