Ruxolitinib is a selective JAK1 and JAK2 inhibitor that targets JAK/STAT-associated signaling, exhibiting an effective clinical treatment of myelofibrosis adopted by FDA (Chang et al., 2019), which was used to confirm the effect of ENC1 on activation of the JAK2/STAT5/AKT axis in CRC cells. The gene discussed is JAK1; the disease is colorectal carcinoma.