Reportedly, Treg cells (CD8+ FOXP3+) have a neglected but strong suppressive effect on the immune system in colon cancer (Chaput et al., 2009), but the function of Treg cells (CD8+ FOXP3+) in LSCC is less widely studied (Hao et al., 2020). Here, CD8A is linked to malignant colon neoplasm.