ENS_06770 (Tmtc2) encodes an endoplasmic reticulum tetratricopeptide repeat-containing adapter protein involved in calcium homeostasis that has been associated with primary open-angle glaucoma (Sunryd et al., 2014; Choquet et al., 2018; Graham et al., 2020). This evidence concerns the gene TMTC2 and open-angle glaucoma.