GABRA1, along with GABRB3, is vital for the formation of GABAA receptors and plays a pivotal role in GABAergic signaling that protects neurons in the brain from over-signaling, which can often lead to diseases such as epilepsy (McKernan et al., 1991; Tozuka et al., 2005). This evidence concerns the gene GABRB3 and epilepsy.