PSMB8 and central nervous system cancer: PSMB8 is involved in the degradation of cytoplasmic antigen processing to generate MHC I binding proteins via stimulation by IFNγ production, provides instructions to make one subunit of immunoproteasomes responsible for helping in response to infections, and also regulates glioma cell migration proliferation and apoptosis (Agarwal et al., 2010; Basler et al., 2018a; Basler et al., 2018b; Yang et al., 2018).