TIGIT and colorectal carcinoma: Research by Garrett WS et al. found that Fusobacterium nucleatum can bind cadherin and inhibitory immune receptor TIGIT on the surface of CRC cells through adhesin FadA and Fap2, respectively, to activate oncogenic Wnt/beta-catenin signaling pathway and inhibit the function of tumor infiltrating lymphocytes and natural killer cells, thereby promoting the development of CRC (Garrett, 2019).