They found that Pa can bind to the integrinα2/β1 on the surface of CRC cells through its surface protein PCWBR2, and activate the downstream PI3K-Akt-NF-κB signaling pathway, thereby driving the occurrence of CRC (Wong et al., 2017; Long et al., 2019). The gene discussed is NFKB1; the disease is colorectal carcinoma.