Lachnospiraceae_FCS020_group was significantly increased in the OM group, which was highly positively correlated with inflammatory cytokines ICAM-1, VCAM-1, KCIL8, CD40L, MCP-1, GM-CSF, and serum LPS; Ruminococcaceae_UCG-009 was significantly increased in the OM group, which was highly positively correlated with inflammatory cytokines CD40L and MCP-1; Acetatifactor is positively associated with MCP-1 while Lachnoclostridium is positively associated with GM-CSF, which was also significantly increased in the OM group. The gene discussed is CD40LG; the disease is ocular melanoma.