PTGS2 and cancer: COX2 pathway has been extensively studied in the EBV mediated tumorigenesis, and EBV induced proliferation of B lymphocytes and COX2, PGE2, and PGE2 receptors EP 1-4 are frequently over-expressed in EBV positive cancer cells in people with chronic inflammatory conditions, Burkitt’s lymphoma, and NPC (Gandhi et al., 2015).