PTGS2 and primary effusion lymphoma: COX2, its lipid metabolite PGE2, PGE2 receptors, or eicosanoid receptors (EP1-4) have been widely studied in KSHV associated diseases such as endothelial cell tumor KS and PEL (George Paul et al., 2010; Sharma-Walia et al., 2010; Paul et al., 2011; Paul et al., 2013).