For instance, CVBD inhibits colorectal cancer tumorigenesis via the CTHRC1-AKT/ERK-Snail signaling pathway (14), and exerts anticancer effects by suppressing the EGFR-FAK-AKT/ERK1/2-Slug signaling pathway in human hepatocellular carcinoma (15). Here, AKT1 is linked to colorectal cancer.