Interaction pairs between TFs and PRSGs with |correlation coefficient| > 0.30 and P value < 0.05 along with interaction pairs between PRSGs and hallmarks of cancer with P value < 0.05 were used to construct the regulation network among TFs, four key PRSGs (CACNA1E, LINC01356, CGA, and SSX3) and hallmarks of cancer. This evidence concerns the gene CACNA1E and cancer.