Furthermore, analogous results were discovered in mouse H22 hepatocellular carcinoma, with an enhanced anti-tumor immune response; the inhibition of tumor growth; and the suppression of interleukin-6 (IL-6), granulocyte colony-stimulating factor (G-CSF), and keratinocyte-derived chemokine (KC). This evidence concerns the gene CSF3 and hepatocellular carcinoma.