Additionally, we dissected the leukemia driven BM and adipocytic niches dysfunctions and showed that the AML/ALL LSCs derived exosomes increase adipolysis genes, adipose triglyceride lipase (ATGL) & hormone sensitive lipase (HSL) to increase the FFAs pool for the proliferating leukemic cells to drive their FAO reliant OXPHOS (13). The gene discussed is PNPLA2; the disease is acute myeloid leukemia.