Indeed, non-aggressive MCF-7 and aggressive MDA-MB-231 breast cancer cells (10) show diverse tumor behaviors in response to TNF-α, including cancer cell proliferation and migration to the TNF-α-induced tumor response (11–13) due to discrepancies in TNF-α-mediated NF-κB activation (14, 15). This evidence concerns the gene NFKB1 and cancer.