By performing GSEA, the malignant hallmarks of IGF2BP2 in HNSCC were analyzed and may include basal cell carcinoma, the Wnt signaling pathway, the Hedgehog signaling pathway, and some signaling pathways related to tumor immunology, such as primary immunodeficiency and the intestinal immune network for IgA production. This evidence concerns the gene IGF2BP2 and inborn error of immunity.