TMPRSS4 and neoplasm: The mRNA expression profiles of the GSE62165, GSE15471, GSE62452, and GSE16515 datasets from the GEO database (https://www.ncbi.nlm.nih.gov/geo/) were analyzed and showed a significant overexpression of TMPRSS4 mRNA in pancreatic cancer tissue as compared to the non-tumor tissue (Figures 1A–D).