MIEN1 and cancer: Here, we speculate a bimodal role for miR-940 that could explain its increase in serum from cancer patients: (1) miR-940 is exported out of the cancer cells to prevent the down regulation of MIEN1, and other proteins predicted as targets inside the cell that aid in cancer progression (32–34, 36, 58) and (2) the secreted miR-940 facilitates the microenvironment remodeling to allow cancer progression (40, 59).