IL18 and subcutaneous panniculitis-like T-cell lymphoma: They also observed elevated serum levels of IFN-γ-induced CXCL10, inflammasome-activated interleukin-18 (IL-18), and soluble CD25 in a HAVCR2 mutant SPTCL patient at the time of active disease, and increased amounts of tumor necrosis factor-α (TNF- α) and IL-2 produced in vitro by T lymphoblasts from HAVCR2 mutant patients with SPTCL.