For comparison, we isolated FOXP3+CD4+ T cells in our SPTCL scRNA-seq data and found that the proportion (21.97%) of FOXP3+CD4+ T cells in CD4+ T cells in our patient was similar to that in TIM-3 wild-type SPTCLs and higher than that in TIM-3 mutants in the reported cohort, consistent with their finding (Supplementary Figure S6). This evidence concerns the gene HAVCR2 and subcutaneous panniculitis-like T-cell lymphoma.