VCAM-1 can tether macrophages to cancer cells via counter-receptor α4β1-integrins, and we found that macrophages and fibroblasts in the SPTCL microenvironment highly expressed ITGA4 and ITGB1, which constitute α4β1-integrins. This evidence concerns the gene ITGB1 and subcutaneous panniculitis-like T-cell lymphoma.