As expected, the top upregulated genes in the malignant cells were GNLY and the granzyme subfamily (e.g., GZMA, GZMK) (Supplementary Figure S10). We further identified potential novel markers for SPTCL including CYTOR, CXCL13, VCAM1, and TIMD4, which were specifically differentially expressed in the SPTCL cells as defined by average fold change > 2 and delta percentage > 90% in malignant T cells versus normal T cells (Figure 3D). This evidence concerns the gene GNLY and subcutaneous panniculitis-like T-cell lymphoma.