The alternative polarization, induced by Th2-derived cytokines (e.g., IL-4, IL-10, IL-13) that hamper the production of pro-inflammatory cytokines such as TNF-α and IFN-γ, gives rise to the pro-tumor M2 macrophage phenotype (10, 25, 45, 46). The gene discussed is IFNG; the disease is neoplasm.