HOTAIRM1 and central nervous system cancer: In addition, HOTAIRM1 expression was detected in the malignant transformed fibroblasts (t-FB1 and t-FB2), normal fibroblasts, glioma cell lines (SNB19, A172, U343), GSCs-SU3, and normal human astrocytes (NHAs), which disclosed HOTAIRM1 upregulation in glioma cell lines, GSCs, and transformed fibroblasts, when compared with NHAs and normal fibroblasts (Figure 1E).