HOTAIRM1 and central nervous system cancer: LncRNA HOTAIRM1 is located in the HOX gene cluster and regulates the family of HOXA genes (22), which is associated with tumor progression, including colorectal (23), gastric (24), lung cancers (25), and pancreatic cancer (26), et al. However, the role of HOTAIRM1 played in interactions between GSCs and stromal cells in glioma microenvironment has never been reported previously.