Previous studies reported that Lnc HOTAIRM1 can act as promoter or suppressor in tumor development: HOTAIRM1 exerted its tumor inhibitory effect through competitive combination with endogenous RNA in gastric cancer (24), head and neck tumor (52), it also can suppress tumor cell proliferation and promote cell apoptosis in hepatocellular carcinoma via inhibiting Wnt pathway (53). Here, HOTAIRM1 is linked to head and neck neoplasm.