Some research (16) suggested that miR-21-3p suppressed growth and induced apoptosis in HepG2 cells by targeting MAT2A and MAT2B, but other research (17) found that suppression of miR-21-3p enhanced TRAIL-mediated apoptosis in liver cancer stem cells by suppressing the PI3K/Akt/Bad cascade via regulation of PTEN. The gene discussed is MAT2A; the disease is liver cancer.