A1AG, Alpha-1 acid glycoprotein; CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; ESRD, end-stage renal disease; IVC, inferior vena cava; MHD, maintenance hemodialysis; pro-BNP, Pro-brain natriuretic peptide; PH, pulmonary hypertension. Here, ORM1 is linked to stage 5 chronic kidney disease.