A great number of previous researches reported increased plasma and serum levels of several systemic inflammatory markers in patients with mild, moderate and severe OSAHS compared with healthy controls, including TNF-α, C-reactive protein (CRP), IL-8, IL-6, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) [97]. The gene discussed is CRP; the disease is obstructive sleep apnea syndrome.