NF-κB signal pathway is related to the expression of M1 phenotype genes (IL-1, IL-2, IL-6, IL-12, TNF-α, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2)), playing a detrimental role in ischemic stroke[50, 54]. Here, NFKB1 is linked to ischemic stroke.