AD-MSCs secrete pro-angiogenic factors, such as Vascular Endothelial Growth Factor (VEGF), platelet-derived growth factors (PDGF), inducing proliferation of endothelial cells, promoting the vascularization, providing physical Extracellular Matrix (ECM) guidance cues that promote endothelial sprouting [36,37]. The gene discussed is VEGFA; the disease is Alzheimer disease.