Deficiency of anticoagulation proteins, including anti-thrombin III, protein C and S and factor V Leiden is associated with inherited thrombophilia which enhances the hypercoagulability state in patients on HD.9-11 Investigating the role of inherited thrombophilia factors may help decrease the risk of catheter failure due to thrombosis in such patients. Here, F5 is linked to Rare hereditary thrombophilia.