ACE2 is a homolog of angiotensin-converting enzyme and is able to generate angiotensin 1-9 from angiotensin I and angiotensin 1-7 from angiotensin II.24 These functions are allowing ACE2 to have an impact on the renin-angiotensin system; thereby, affecting the cardiac and renal function.24,25 However, the expression of this enzyme is not limited to heart and kidneys and it also can be found in lungs and colon.25 Recently, researches have shown that post-CoV-infection lung failure and cardiovascular diseases (CVDs) are happening due to the down-regulation of ACE2.26,27. This evidence concerns the gene ACE2 and cardiovascular disorder.