This effect was not seen when NK cells were exposed to microvesicles obtained from the sera of healthy donors and the use of TGF‐β1‐neutralizing antibodies restored normal NK cells functionality in the co‐cultures, indicating that the observed results could be specifically attributed to the immunosuppressive signaling by TGF‐β1 enclosed in tumour‐shed microvesicles (Szczepanski et al., 2011). This evidence concerns the gene TGFB1 and neoplasm.