Therefore, although specific studies are necessary and the details of MΦ/MG polarization kinetics during the various stages of COVID-19 and its association with pathogenesis need to be unraveled, it is highly probable that MΦ/MG involved in the first phases of SARS-CoV-2 infection are M1-polarized and HIF-1α expressing and perform aerobic glycolysis. The gene discussed is HIF1A; the disease is COVID-19.