For the preparation of this article, an Ovid literature search was conducted with Medline, Embase, and Biosys as the databases, on anti-IgE treatment in AD from January 2002 to May 2020 The search terms used included omalizumab, anti-IgE, atopic dermatitis, allergic dermatitis, and atopic eczema. Here, IGHE is linked to atopic eczema.