Based on the results of this study, the highest degree value target of SDSZT for dry age-related macular degeneration is PTSG2, while AKT1, PTGS1, TNF, JUN, BCL2, CASP3, PIK3CG, AR, and BAX are also likely to be key therapeutic targets for SDSZT. Here, AKT1 is linked to dry age related macular degeneration.