For example, five (i.e., OR5K2, INPP1, PDHB, ITPR3, and ICAM5) show a higher overall genetic effect on SLE, while the rest (i.e., CTD-3105H18.4, MAG13, CLIP2, INF5, TYK2, CCDC116, and RP11-387H17.4) show a higher overall genetic effect on RA. The gene discussed is ICAM5; the disease is rheumatoid arthritis.