In this study, our results showed that the mRNA levels of S100A4/S100A6/S100A10/S100A11/S100A13/S100A14/S100P were significantly upregulated in HCC patients, while the S100A8/S100A9/S100A12 mRNA levels were decreased. The gene discussed is S100A13; the disease is hepatocellular carcinoma.