Apart from S100A5, S100A7, S100A7A, S100A12, S100A13, S100A16, S100B, S100P, S100G, S100Z, the rest family members, such as S100A1, S100A2, S100A3, S100A4, S100A6, S100A8, S100A9, S100A10, S100A11, S100A14, and S100P are shown to be expressed in HCC (Wang et al., 2001; Kittaka et al., 2008; Hua et al., 2011; Luo et al., 2013; Yan et al., 2013; Zhao et al., 2013; De Ponti et al., 2015; Tao et al., 2017; Guo et al., 2018). The gene discussed is S100A9; the disease is hepatocellular carcinoma.