Case 3 also carries a variant in the CRB2 gene, the HLA-DRB1*03 allele related to NMOSD (Zéphir et al., 2009; Brum et al., 2010; Deschamps et al., 2011), and haplotype DRB1*11:01-DQA1*05:01-DQB1*03:01, associated with lupus erythematosus (Miyagawa et al., 1997; Table 3, Supplementary Table 2). This evidence concerns the gene CRB2 and lupus erythematosus.