HLA-DRB5 and autoimmune disease: Patient 19ZC160 also carries the HLA haplotype DRB1*15:01-DQA1*01:02-DQB1*06:02-DRB5*01:01, associated with CNS demyelination and autoimmune disease (Dyment et al., 2005; Kaushansky and Ben-Nun, 2014; Mack et al., 2019), and the DPA1*01:03 and DPB1*04:01 alleles, associated with narcolepsy (Cortes et al., 2004; Louthrenoo et al., 2013; Table 3, Supplementary Table 2).