The demyelinating lesions found in most MS and NMOSD patients are mainly associated with T cell inflammation, with the involvement of both microglia and infiltrating peripheral macrophages - as revealed by TMEM119 immunohistochemical profiling - in the pathology of the lesions (Popescu and Lucchinetti, 2012; Zrzavy et al., 2017; Hayashida et al., 2020). This evidence concerns the gene TMEM119 and myeloid sarcoma.