These include the regulation of OXPHOS enzyme levels, reduced cellular ATP levels, pathological morphology of mitochondria, ROS generation, impaired glucose tolerance, reduced glucose-induced insulin secretion, and increased anxiety-related behavior, resulting in significant differences in health and longevity between various conplastic strains (Yu et al., 2009; Weiss et al., 2012; Houstek et al., 2014; Latorre-Pellicer et al., 2016). This evidence concerns the gene INS and Anxiety.