For that reason, we hypothesized that CDK5RAP2 variants might interact as a second hit effect in the existence of congenital ZIKV infection as in the present case their father is a carrier of p.Thr274LysfsTer27 and p.Glu275ArgfsTer16 without any specific phenotype. This evidence concerns the gene CDK5RAP2 and Zika virus infectious disease.