When we evaluated in untreated MAS/sHLH patients and in all MAS/sHLH patients (treated and untreated) the correlations of pSTAT1 and total STAT1 with clinical and laboratory parameters, including white blood cell count, platelet count, hemoglobin, ferritin, fibrinogen, we did not find any statistically significant correlation (data not shown). The gene discussed is STAT1; the disease is macrophage activation syndrome.