Along this line, mitochondrial HSP70 homolog GRP75/mtHSP70/mortalin/HSPA9 showed to interact with complement C9 and protect tumor cell from complement-dependent cytotoxicity (232–234).Furthermore, HSPs regulate an important component of innate immune response- the Nod-like receptor protein-3 (NLRP3) inflammasome (235, 236). The gene discussed is NLRP3; the disease is neoplasm.