Subsequently, Goldstein and co-workers used PU-H71 and tumor-enriched HSP90 (teHSP90) complexes derived from DLBCL cell lines to show that LYN, SYK, BTK and phospholipase C γ 2(PLCγ2) are dependent on teHSP90 (110). The gene discussed is HSP90AA1; the disease is diffuse large B-cell lymphoma.