One of the major hallmark of lymphoma is represented by the deregulated critical signaling pathways including NF-kB, JAK-STAT, BCR signaling, PI3K/AKT, MAPK/ERK and apoptosis signaling pathways (82, 85–88, 190).Noticeably, specific members of HSP families, in particular, HSP90 showed to interfere with all these signaling cascades (83, 89, 103). This evidence concerns the gene BCR and lymphoma.