Valbuena and colleagues reported moderate-to-strong cytoplasmic expression of HSP90 in 100% of cases of BL,61% of FL patients, 59% of DLBCL, 38% of nodal MZL and 33% of cases with SLL/CLL and 30% of lymphoplasmacytic lymphoma (119). This evidence concerns the gene HSP90AB1 and B-cell chronic lymphocytic leukemia.