Furthermore, aberrant expression of mitogen-activated protein kinase (MAPK)/ERK has been reported in HL (88).In light of the reported, HSP90 inhibitor 17-AAG showed to deplete AKT and inhibit extracellular signal-regulated kinase (ERK) phosphorylation, leading to growth arrest and apoptosis in HL cell lines (89) (88). This evidence concerns the gene HSP90AA1 and Hodgkins lymphoma.