Similarly, the elevated expression of GPC3 in >70% of HCC, and its association with poor prognosis (121), has led to the development of several immunotherapeutic strategies, including the humanized monoclonal antibody codrituzumab (122), bi-specific antibodies (123), CAR-T cells (124), antibody-drug conjugates (125), and vaccines (126). The gene discussed is GPC3; the disease is hepatocellular carcinoma.