iCluster 1 is associated with poorer differentiation, higher tumor grade, the presence of macrovascular invasion and overexpression of proliferation (PLK1, MKI67) and progenitor cells (EPCAM and AFP) gene markers, while iCluster 3 is characterized by high frequency of TP53 mutation, 17p loss and activation of WNT-TGFβ signaling. This evidence concerns the gene TGFB1 and neoplasm.