A diverse repertoire of functionally distinct myeloid cells were identified, particularly, two subsets of macrophages within the tumors: THBS1+ macrophages enriched in myeloid-derived suppressor cell (MDSC) genes (S100A genes, FCN1 and VCAN) and C1QA+ macrophages, enriched in tumor associated macrophage (TAM) genes APOE, C1QB and TREM2 (Figures 3, 5). This evidence concerns the gene TREM2 and neoplasm.