Accordingly, activating mutations in CTNNB1 correlate with resistance to ICI monotherapy with either anti-PD-1 or anti-PD-L1, as shown in a prospective sequencing analysis of 27 evaluable advanced HCC patients, in which none of the 10 patients with WNT pathway alterations achieved clinical benefit, whereas around half of the non-WNT pathway–altered patients showed durable stable disease (93). Here, CTNNB1 is linked to hepatocellular carcinoma.