CD27 and systemic lupus erythematosus: Using deposited RNAseq data (Supplementary Data File 2) from SLE patients (Supplementary Table 1) (1), principal component (PC) analysis revealed that CD11chi IgD+ and IgD− may be separate populations, but they are vastly different from naive (CD11c− CD27− IgD+) and memory (CD11c− CD27+ IgD−) B cells (Figure 1A).