Our transcriptional analysis (Table 1) showed that CD11chi IgD+ and IgD− B cells from SLE patients have decreased expression of CR2 (CD21), CD27, and CXCR5 consistent with B cell populations from RA and combined variable immunodeficiency (CVID) described in the literature as anergic (7) (CD21− CD27−), DN2 from SLE patients (3) (CD27− IgD− CXCR5−), atypical from malaria patients (21) (CD21− CD27−), and FCRL4+ tissue memory B cells from tonsil (36). The gene discussed is CR2; the disease is malaria.