For example, host NOD-like receptor family pyrin domain-containing 6 (NLRP6) regulates microbiota-dependent protection in intestinal colitis and tumorigenesis (110–113), but Tomomi et al. found an inverse effect in GVHD, in which host NLRP6 played a pathogenic role in aggravating intestinal damage (105). This evidence concerns the gene NLRP6 and graft versus host disease.