Although the percentages of TFR cells in the whole population of pSS patients were similar to that of healthy controls, when patients were divided into two subgroups based on the presence or absence of autoantibodies, we found that the proportion of TFR cells in patients having anti-Ro/SSA antibodies was significantly higher than those measured in autoantibody negative patients (p = 0.0363, Figure 1G). The gene discussed is TRIM21; the disease is peeling skin syndrome.