Type 1 interferonopathies identified in the cohort included patients with DADA2 (six patients; five families); STING-associated vasculopathy infantile-onset (SAVI) (three patients from one family); Spondylo enchondro dysplasia with Immune Dysregulation (SPENCD) (two patients) and Coatamer complex one protein alpha subunit (COPA syndrome) (one patient) (Table 1). The gene discussed is STING1; the disease is Spondyloenchondrodysplasia with immune dysregulation.