Type 1 interferonopathies identified in the cohort included patients with DADA2 (six patients; five families); STING-associated vasculopathy infantile-onset (SAVI) (three patients from one family); Spondylo enchondro dysplasia with Immune Dysregulation (SPENCD) (two patients) and Coatamer complex one protein alpha subunit (COPA syndrome) (one patient) (Table 1). This evidence concerns the gene STING1 and vascular disorder.