We observed that AD treatment markedly upregulated Blimp-1 expression and downregulated PAX-5 expression in B cells, whereas, it did not exert any significant effect on XBP-1 and Bcl-6 expression (Supplementary Figure 7), which indicates that Blimp-1 might be involved in AD-induced B-cell differentiation. The gene discussed is PAX5; the disease is Alzheimer disease.