The present study showed that AD-induced PI3K/Akt1/STAT3 activation upregulated Blimp-1 expression and promoted B-cell differentiation, in which PI3K/Akt1-activated STAT3 bound to the Blimp-1 gene promoter and induced transcription, indicating that the activation of the PI3K/Akt1/STAT3 axis could play an important role in regulating B-cell differentiation in response to AD stimulation. This evidence concerns the gene PIK3CD and Alzheimer disease.