To evaluate the possible roles of PI3K/Akt1 and STAT3 in Blimp-1 expression and AD-induced B-cell proliferation and differentiation, purified B cells were transfected with siPI3K, siAkt1, siSTAT3, or siCTR followed by AD stimulation, following which B-cell proliferation and differentiation were evaluated. The gene discussed is PRDM1; the disease is Alzheimer disease.