Nonetheless, the mIL-15 complex could be cleaved from the surface to form soluble IL-15–IL-15Rα complex (sIL-15 complex) in response to several immune stimuli, including type I interferons (type I IFNs), Poly I:C stimulation, total body irradiation (TBI), Toll-like receptor (TLR) stimulation, virus infections, and activation of the stimulator of IFN genes (STING) pathway (57, 69, 70). This evidence concerns the gene IL15 and viral infectious disease.