The superior activity of A24 compared to the iron chelator may be explained, at least in part, by the contribution of antibody effector functions such as ADCC and CDC, the ability of the antibody to induce specific TfR1 downregulation in cancer cells expressing high TfR1 levels, and the possibility that the iron chelator induces TfR1 messenger RNA stability through a post-transcriptional mechanism (128, 134). Here, TFRC is linked to cancer.