The murine anti-human TfR1 IgG antibody 7579 downregulates TfR1 surface levels on cancer cells (132) and has shown efficacy in mitigating in vitro proliferation as well as inducing apoptosis of human U87MG, U251, and A172 glioma cells, human HepG2 hepatoma cells, and human MCF7 breast cancer cells (120–122, 132). The gene discussed is TFRC; the disease is cancer.