The other way is to use the antibodies themselves as anti-cancer agents, utilizing their ability to directly inhibit TfR1 function and/or activate antibody-mediated effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cell-mediated phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC). The gene discussed is TFRC; the disease is cancer.