In contrast, module 3 (M3) segregated in a different cluster of cytokines that include low IL-1β, IL-2, IL-12, moderate IL-17, IL-21, and high IFNγ, GM-CSF that were associated with low levels of lymphocytes and low titers of total IgG and IgG1 in the acute phase of infection. The gene discussed is IL21; the disease is infection.