In contrast, module 3 (M3) segregated in a different cluster of cytokines that include low IL-1β, IL-2, IL-12, moderate IL-17, IL-21, and high IFNγ, GM-CSF that were associated with low levels of lymphocytes and low titers of total IgG and IgG1 in the acute phase of infection. This evidence concerns the gene IL1B and infection.