This is concordant with the reduced level of BANK1 observed after B cell activation and in differentiated cells, as tumor B cells (GSE 22529) or plasma cells (GSE 6691), since Breg cells have also been shown to be highly differentiated cells (8, 76–80) and GZMB+ Bregs are enriched in plasmablast population (10). Here, BANK1 is linked to neoplasm.