Thus, functional variants of BANK1 are associated with SLE (52, 54, 61–63), rheumatoid arthritis (64), diffuse cutaneous systemic sclerosis (65, 66), multifocal motor neuropathy (67), type I diabetes (68), autoimmune thyroid disease (69), B cell lymphoma (70), LDL cholesterol (71), psoriasis (72), primary Sjogren’s syndrome (73), polymyositis/dermatomyositis (74), and systemic sclerosis (75), pointing an important functional role for BANK1 in immune system, without, however explaining its role. This evidence concerns the gene BANK1 and systemic lupus erythematosus.