Thus, functional variants of BANK1 are associated with SLE (52, 54, 61–63), rheumatoid arthritis (64), diffuse cutaneous systemic sclerosis (65, 66), multifocal motor neuropathy (67), type I diabetes (68), autoimmune thyroid disease (69), B cell lymphoma (70), LDL cholesterol (71), psoriasis (72), primary Sjogren’s syndrome (73), polymyositis/dermatomyositis (74), and systemic sclerosis (75), pointing an important functional role for BANK1 in immune system, without, however explaining its role. This evidence concerns the gene BANK1 and systemic sclerosis.