MAIT cells from patients with PBC, stimulated with IL-18, significantly upregulated the production of IFN-γ (74.9 ± 6.6% vs. 54.7 ± 6.7%, p < 0.01), which was partially blocked by IL-18Rα/IL-1R5 antibody (68.6 ± 8.3% vs. 43.5 ± 4.2%, p < 0.01, Figure 4C). The gene discussed is IL18; the disease is primary biliary cholangitis.