IFN-γ is important in the protective mechanism against hepatic fibrosis, while TNF can aggravate the pathogenesis (Henri et al., 2002; Booth et al., 2004), due to its roles in activating hepatic stellate cells and collagen deposition (Pradere et al., 2013; Yang and Seki, 2015). The gene discussed is IFNG; the disease is Hepatic fibrosis.