This cleavage is further regulated via phosphorylation by FAM20C (family with sequence similarity 20, member C, also known as DMP4; the gene mutated in Raine syndrome) and O-glycosylation by GALNT3 (polypeptide N-acetylgalactosaminyltransferase 3) (63–65). Here, FAM20C is linked to lethal osteosclerotic bone dysplasia.